Know thy star, know thy planet — or not?

Know thy enemy

We recently described hypoxia as one of the leading mechanism for the recruitment of regulatory T cells (Treg) through CCL28 chemokine in ovarian cancer. Treg promote progression of cancer through tumor-specific immune paralysis but also reprogramming of angiogenesis. We review these mechanisms and discuss the challenges and opportunities for therapy targeting Treg.

Know Thy Toucher

Most of current academic and commercial surface computing systems are capable of multitouch detection and hence allow simultaneous input from multiple users. Although there are so far only few applications in this area which rely on identifying the user, we believe that the association of touches to users will become an essential feature of surface computing as applications mature, new applicat...

Know Thy Participant 1 Running Head: KNOW THY PARTICIPANT Know Thy Participant: The Trouble with Nomothetic Assumptions in Moral Psychology

Brain, Know Thy Transcriptome, Know Thyself

In this issue of Neuron, Konopka et al. (2012) describe their comparison of transcriptomes from frontal pole, caudate nucleus, and hippocampus of multiple adult humans, chimpanzees, and rhesus monkeys. The data provide an initial opportunity for linking genomic and brain differences among these primate species.

Know Thy Source Code. Is it mostly dead or alive?

Nowadays, even small systems contain numerous components with complex dependencies. These components differ in importance and quality. Some of them get deprecated over time and can be removed from the project. This leads to the question relevant for all architects: which parts of my source code are still alive? To answer this question we harness the graph-based model of software. We perform a d...